Mr Smith, a 50 year old man weighing 70 kg, requires an oral loading dose of digoxin. Which one of the following should be suggested to aim for a plasma concentration of 1.5 micrograms/litre?
You are given that the Volume of Distribution, Vd, per kg body weight is 6 litres; the Salt Factor S = 1; the Bioavailability F= 0.7; and the formula, where Cp is the Target Plasma Concentration:
A. A total dose of 1200 micrograms in four divided doses
B. A total dose of 500 micrograms as a stat dose
C. A total dose of 900 micrograms as a stat dose
D. A total dose of 500 micrograms in two divided doses
E. A total dose of 900 micrograms in three divided doses
You are given that the Volume of Distribution, Vd, per kg body weight is 6 litres; the Salt Factor S = 1; the Bioavailability F= 0.7; and the formula, where Cp is the Target Plasma Concentration:
Loading dose = (VdxCp)/(SxF)
A. A total dose of 1200 micrograms in four divided doses
B. A total dose of 500 micrograms as a stat dose
C. A total dose of 900 micrograms as a stat dose
D. A total dose of 500 micrograms in two divided doses
E. A total dose of 900 micrograms in three divided doses
No comments:
Post a Comment